Convenient synthesis of a new class of N2SO or N2S2 tetradentate ligands suitable for nuclear medicine applications

摘要

In our search for a Tc-99m labelled brain perfusion imaging agent, six new tetradentate acyclic ligands have been synthesised in good yield, through easy and fast syntheses. These compounds possess an aromatic ring bridging a nitrogen and an oxygen or a sulfur and contain two amides (1a, 1b) or an amine and an amide functionalities (2a-2d), which make them good candidates for radiopharmaceuticals. [References: 11]