Regioselective propargylation of carbonyl compounds with (3-bromo-prop-1-ynvl)trimethylsilane promoted by reactive barium

摘要

A Barbier-type propargylation of aldehydes with (3-bromoprop-1-ynyl)trimethylsilane has been achieved using reactive barium as a low-valent metal in THE This process is effective also for obtaining the desired homopropargylic alcohols in high yields from the corresponding ketones including enolizable ketones such as cyclopent-2-enone.