Aminomethylation via Cyclopalladated-Ferrocenylimine-Complexes-Catalyzed Suzuki–Miyaura Coupling of Aryl Halides with Potassium N,N-Dialkylaminomethyltrifluoroborates

摘要

Using cyclopalladated ferrocenylimine complexes (1-3 mol%) as catalysts, the Suzuki–Miyaura coupling of potassium N,N-dialkylaminomethyltrifluoroborates with aryl and heteroaryl halides were carried out in a 10:1 THF–H_2O mixture at 80 ℃ in the presence of Cs_2CO_3 (3.0 equiv) as base, giving the desired cross-coupling products in 14-87% yields. A variety of potassium alkyl-trifluoroborates were also examined.