Catalytic asymmetric formation of secondary allylic amines by aza-claisen rearrangement of trifluoroacetimidates

摘要

A catalytic asymmetric synthesis of unprotected secondary allylic ammes based on the aza-Claisen rearrangement of N-aryl- and N-alkyl-substituted trifluoroacetimidates has been developed, which provides the targeted products with excellent enantioselectivity.