Zirconium-Catalyzed Friedel-Crafts Alkylation of Pyrrole

摘要

The zirconium-catalyzed enantio-selective Friedel-Crafts alkylation of pyrrole with2,2,2-trifluoroacetophenones is reported. The re-sulting pyrroles with a trifluoromethyl-substitutedtertiary alcohol moiety are afforded in high yieldand enantioselectivity. In addition, the BINOL-typeligands are commercially available in both enantio-meric forms. Thus, this procedure enables readyaccess to both enantiomers of the target com-pounds.