Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

Matsumoto N; Hirose R; Sasaki S; Fujita T

首页> 外文期刊>Chemical and Pharmaceutical Bulletin >Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

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Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

机译：免疫调节剂FTY720（芬戈莫德）的关键中间体2-乙酰氨基-2-（2-（4-辛酰基苯基）乙基）丙烷-1,3-二甲酸二乙酯的合成。

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The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).

机译：免疫调节剂FTY720（2：芬戈莫德）的关键中间体2-乙酰氨基-2-（2-（4-辛酰基苯基）乙基）丙烷-1,3-二甲酸二乙酯（13）是通过迈克尔加成二乙基（乙酰氨基）丙二酸酯（6）变成4-辛酰基苯乙烯（12）。

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《Chemical and Pharmaceutical Bulletin》 |2008年第4期|共3页
作者
Matsumoto N; Hirose R; Sasaki S; Fujita T;
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正文语种 eng
中图分类药学;化学;
关键词
Immunologic Factors; Indicators and Reagents; Magnetic Resonance Spectroscopy; 免疫因子; 指示剂和试剂; 分光光度法; 红外线; 鞘氨醇;

机译：Immunologic Factors;Indicators and Reagents;Magnetic Resonance Spectroscopy;免疫因子;指示剂和试剂;分光光度法;红外线;鞘氨醇;

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1. Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod). [J] . Matsumoto N, Hirose R, Sasaki S, Chemical and Pharmaceutical Bulletin . 2008,第4期

机译：免疫调节剂FTY720（芬戈莫德）的关键中间体2-乙酰氨基-2-（2-（4-辛酰基苯基）乙基）丙烷-1,3-二甲酸二乙酯的合成。
2. Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2(2-(-4-octylphenyl)ethyl)propane-1,3-diol hydrochloride) in rats after oral and intravenous doses. [J] . Meno Tetang GM, Li H, Mis S, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2006,第9期

机译：口服和静脉内给药后，FTY720（2-氨基-2（2-（-4-（-4-辛基苯基）乙基）丙烷-1,3-二醇盐酸盐）的生理基础药代动力学模型。
3. Synthesis and characterization of diethyl-dithiocarbamic acid 2-[4-(2-diethylthiocarbamoylsulfanyl-2-phenyl-acetyl)-2,5-dioxo-piperazin-1-yl]-2-oxo-1-phenyl-ethyl ester as new reversible addition-fragmentation chain transfer agent for polymerization of ethyl methacrylate [J] . Abdollahi Elaheh, Abdouss Majid, Salami-Kalajahi Mehdi, Designed Monomers and Polymers: An International Journal on Monomer and Macromolecular Synthesis . 2016,第1期

机译：新型二乙基二硫代氨基甲酸2- [4-（2-二乙基硫代氨基甲酰基硫烷基-2-苯基-乙酰基）-2,5-二氧-哌嗪-1-基] -2-氧代-1-苯基-乙酯的合成与表征用于甲基丙烯酸乙酯聚合的可逆加成-断裂链转移剂
4. Synthetic Study towards (±)-Cyanolide A: Synthesis of the Intermediate of (±)-2-(6-ethyl-2-(4-methoxyphenyl)-1, 3-dioxan-4-yl) Acetaldehyde [C] . Xiao Leng, Shuangjie Lin, Zhibin Zhang, International Conference on Advances in Energy, Environment and Chemical Engineering . 2015

机译：朝（±）-CYANOLIDE A：合成（±）-2-（6-乙氧基-2-（4-甲氧基苯基）-1,3-二氧烷-4-基）乙醛的中间体的合成
5. 2-(2-(4-Benzoylpiperazin-1-yl)ethyl)isoindoline-13-dione derivatives: Synthesis docking and acetylcholinesterase inhibitory evaluation as anti-alzheimer agents [O] . Ahmad Mohammadi-Farani, Nasibeh Abdi, Alireza Moradi, 2017

机译：2-（2-（4-苯甲酰基哌嗪-1-基）乙基）异吲哚啉-13-二酮衍生物：合成对接和乙酰胆碱酯酶的抑制性评价作为抗老年痴呆症药物
6. Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod) [O] . Norimasa Matsumoto, Ryoji Hirose, Shigeo Sasaki, 2008

机译：合成免疫调节剂Fty720（Fingolimod）的关键调节剂的键中间体，二乙基氨基-2-（2-（4-辛酰基）乙基）丙烷-1,3-二酯

Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

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