Novel synthesis of ethyl 3-(bromoacetyl)-4,6-dichloro-1H-indole-2-carboxylate as useful intermediate in the preparation of potential glycine site antagonists

摘要

A novel synthesis of ethyl 3-(bromoacetyl)-4,6-dichloro-1H-indole-2-carboxylate is described. The efficient preparation of this key intermediate allowed to obtain the thiazole derivative 2 as potential glycine site N-metyhl-D-aspartate receptor antagonist. [References: 18]