Glil promotes transforming growth factor-betal- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells

摘要

Background. The Hedgehog signaling pathway and its key target effector Gli1 are linked closely to the development of the epithelial to mesenchymal transition (EMT) in many cancers. The definite function of Gli1 in regulating the EMT of pancreatic cancer (PC), however, is still unclear.