The neurobiology of benzodiazepine receptors in panic disorder and post-traumatic stress disorder

摘要

Gamma-aminobutyric acid (GABA) is quantitatively the most important inhibitory neurotransmit-ter in the central nervous system, and benzodiazepines (BZs) act via a binding site on the GABA receptor complex. The neurobiology of the GABA-BZ receptor complex is being increasingly understood as imaging and pharmacological techniques to study the receptor complex both indirectly and directly improve. This paper outlines the evidence for BZ receptor abnormalities in panic disorder and post-traumatic stress disorder.