目的：观察卒中后抑郁（PSD）患者血小板膜外周型苯二氮卓受体（PBRs）的变化，探讨PBRs在PSD中的作用。方法：卒中后抑郁组为初发脑梗死后PSD患者43例、脑梗死组为初发脑梗死患者59例、对照组为健康献血者46名。采用Hamilton抑郁量表（HAMD）评定患者抑郁程度。提取外周血血小板膜，应用放射性配基[3 H]PK11195结合实验测定PBRs 特异结合活性。结果：[3 H] PK11195结合活性3组之间有显著差异（P ＜0.01）。与对照组[（298．2±25．1） pmol/（g protein）]比较，脑梗死组[3 H] PK11195结合活性[（1410．8±41．4） pmol/（g protein）]显著升高（P＜0．01）。与脑梗死组比较，PSD组[3 H]PK11195结合活性[（361．7±30．6） pmol/g protein]显著降低（P＜0．01）。 PSD组男性、女性患者之间比较，[3 H]PK11195结合活性差异不显著。 PSD组[3 H] PK11195结合活性与患者病程无显著相关性（r＝0．27，P＞0．05），与HAMD评分呈显著负相关（r＝-0.44，P＜0.01）。结论：PSD患者血小板膜PBRs结合活性下降， PBRs影响抑郁程度。%AIM: To evaluate the changes of peripheral-type benzodiazepine receptors (PBRs) in platelet membrane in post-stroke depression (PSD) patients and to investigate the effects of PBRs on PSD .METHODS: Forty-three patients with PSD, fifty-nine patients with first-ever cerebral infarction and fifty-six healthy volunteers participated in this study.Platelet membrane in venous blood was prepared .Binding assay of the radioactive PBRs antagonist [ 3 H] PK11195 to platelet membrane was performed .RESULTS: A significant difference of [ 3 H]PK11195 binding was found among the 3 groups (P<0.01).Compared with the healthy volunteers [(298.2 ±25.1) pmol/(g protein)], a highly significant increase in [ 3 H]PK11195 binding was observed in platelet membrane in the patients with first attack of cerebral infarction [(1 410.8 ±41.4) pmol/(g protein), P<0.01].Compared with the patients with first attack of cerebral in-farction, a significant reduction in [ 3 H] PK11195 binding was detected in platelet membrane in the patients with PSD [(361.7 ±30.6) pmol/(g protein), P<0.01].In the patients with PSD, no significant difference of [ 3 H]PK11195 binding was found between men and women (P>0.05).[ 3 H]PK11195 binding was related to the score of Hamilton de-pression rating scale (r=-0.44, P<0.01) but not to the duration of cerebral infarction (r=0.27,P>0.05).CON-CLUSION:PBRs binding activity in platelet membrane decreases in the patients with PSD and affects the degree of de -pression.
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