Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators

摘要

In 1991 the Clinical Trials Subcommittee of the International Headache Society (IHS) published its first edition of the Guidelines on controlled trials of drugs in migraine . The Guidelines' overarching goal was to improve 'the quality of controlled clinical trials in migraine', which could be achieved by using scientifically robust methods of clinical research. The report highlighted the complex nature of migraine clinical trial methodologies and offered a road map to clinical investigators who were interested in the field.