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Intrinsic properties and regulation of Pannexin 1 channel

机译:Pannexin 1通道的内在特性与调控

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摘要

Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via proteolytic cleavage of the Panx1 C-terminus. Panx1 channels are widely expressed in various cell types, and it is now thought that targeting these channels therapeutically may be beneficial in a number of pathophysiological contexts, such as asthma, atherosclerosis, hypertension, and ischemic-induced seizures. Even as interest in Panx1 channels is burgeoning, some of their basic properties, mechanisms of modulation, and proposed functions remain controversial, with recent reports challenging some long-held views regarding Panx1 channels. In this brief review, we summarize some well-established features of Panx1 channels; we then address some current confounding issues surrounding Panx1 channels, especially with respect to intrinsic channel properties, in order to raise awareness of these unsettled issues for future research
机译:Pannexin 1(Panx1)通道通常表示为释放ATP的非选择性大孔通道。已经描述了Panx1在正常神经,心血管和免疫系统中介导嘌呤能信号转导中的新兴作用,在机械作用,离子型和代谢型受体信号转导中,以及通过Panx1 C末端的蛋白水解切割可激活它们。 Panx1通道在各种细胞类型中广泛表达,现在认为治疗性靶向这些通道在许多病理生理环境中可能是有益的,例如哮喘,动脉粥样硬化,高血压和缺血性癫痫发作。尽管对Panx1频道的兴趣迅速增长,但它们的一些基本属性,调制机制和建议的功能仍存在争议,最近的报道挑战了一些有关Panx1频道的长期观点。在这篇简短的评论中,我们总结了Panx1渠道的一些完善的功能;然后,我们将解决Panx1渠道周围的一些当前令人困惑的问题,尤其是与固有渠道属性有关的问题,以便提高对这些未解决问题的认识,以备将来研究

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