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首页> 外文期刊>SIAM Journal on Numerical Analysis >Mathematical and numerical modeling of solute dynamics in blood flow and arterial walls
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Mathematical and numerical modeling of solute dynamics in blood flow and arterial walls

机译:血流和动脉壁中溶质动力学的数学和数值模型

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摘要

The numerical modeling of solutes absorption processes by the arterial wall is of paramount interest for the understanding of the relationships between the local features of blood flow, the nourishing of the inner arterial wall by the blood solutes, and the pathologies that can appear when this process is for some reason perturbed. In the present work, two models for the solutes dynamics are investigated. In the first model, which is essentially based on the one introduced by Rappitsch and Perktold [J. Biomech. Engrg., 118 (1996), pp. 511-519] and Rappitsch, Perktold, and Pernkopf [Internat. J. Numer. Methods Fluids, 25 (1997), pp. 847-857], the Navier-Stokes equations for an incompressible fluid, describing the blood velocity and pressure fields, are coupled with an advection-diffusion equation for the solute concentration. The wellposedness of this model is discussed. The second model considers also the solutes dynamics inside the arterial wall, described by a pure diffusion equation. Actually, this is a heterogeneous model, coupling different equations in different parts of the domain at hand. Its wellposedness is proven. Moreover, in view of the numerical study, an iterative finite element method by subdomains is proposed and its convergence properties are analyzed. Finally, several numerical results comparing the different models in situations of physiologic interest are illustrated. [References: 31]
机译:对于理解血流的局部特征,血溶质对动脉内壁的营养以及这种过程可能出现的病理之间的关系,动脉壁溶质吸收过程的数值模拟至关重要。由于某种原因感到不安。在目前的工作中,研究了两种溶质动力学模型。在第一个模型中,该模型主要基于Rappitsch和Perktold提出的模型[J.生物机械。 Engrg。118(1996),pp。511-519]和Rappitsch,Perktold和Pernkopf [国际会议。 J.纽默方法,《流体》,1997年,第25期,第847-857页),描述了血流速度和压力场的不可压缩流体的Navier-Stokes方程,与溶质浓度的对流扩散方程相结合。讨论了该模型的适用性。第二个模型还考虑了动脉壁内的溶质动力学,用纯扩散方程描述。实际上,这是一个异构模型,在当前域的不同部分耦合了不同的方程。它的健康性已得到证明。此外,鉴于数值研究,提出了一种基于子域的迭代有限元方法,并分析了其收敛性。最后,举例说明了在生理学情况下比较不同模型的几个数值结果。 [参考:31]

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