A method for non-invasive assessment of peripheral artery disease (PAD) in the peripheral artery/arteries of a patient can include first constructing from medical image data a source model that includes a patient-specific model of the artery/arteries. The method can further include creating a corresponding benchmark model by replacing stenotic segments with idealized segments in the source model and simulating blood flow and blood pressure in the benchmark model to compute reference hemodynamics information. The method can further include generating an assay model by replacing an idealized artery/arteries of interest in the benchmark model with the actual stenotic geometry of the artery/arteries from the source model.
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