PKC delta is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages

摘要

Aims Uptake of oxidized lipoprotein particles (oxLDL) and foam cell formation by macrophages is one of the first steps in the development of atherosclerosis. Recently, protein kinase C delta (PKC delta) has been implicated as a regulator of oxLDL uptake and foam cell formation via down-regulation of PKC beta and scavenger receptors CD36 and SR-A expression. Here, we describe studies in which we have re-evaluated the role of PKC delta in oxLDL uptake and foam cell formation.