Reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their biological activity

摘要

The reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5- arylfuran-2-carboxaldehydes 2,4,5-disubstituted furan-2-carboxaldehydes 3 and thiophene-2- carboxaldehyde 4 has been studied.The advantage of microwave irradiation on some of these reactions was reflected in the reduced reaction time and increased yields.Reactions of 1 with 4-substituted 1,3-oxazol-5(4H)-ones 11 led to diacylhydrazines 13 or to imidazole derivatives 14 depending on the temperature.1,2,4-Triazole-3-thione 17 was synthesized by two-step reaction of 1 with phenylisothiocyanate and subsequent base-catalyzed cyclization of thiosemicarbazide 16.The e?ects of hydrazones 5-10 on inhibition of photosynthetic electron transport in spinach chloroplasts and chlorophyll content in the antialgal suspensions of Chlorella vulgaris were investigated.