Synthesis,structural and conformational study of selected N-substituted phthalimides

摘要

This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT_4 ligands by using the Mitsunobu reaction.Conformational studies of some of the new compounds have been conducted using ~1H and ~(13)C-NMR spectroscopy.Proton and carbon resonances were achieved through the application of one- dimensional selective NOE,two-dimensional NMR techniques-homonuclear COSY-45,NOESY and heteronuclear ~1H-~(13)C HMQC correlated spectroscopy-and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.