Synthesis, structural and conformational study of selected N-substituted phthalimides

摘要

This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT₄ ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques -homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.