Discussion Addendum for: dl-Selective Pinacol-Type Coupling Using Zinc, Chlorosilane, and Catalytic Amounts of Cp2VCl2; dl-1,2- Dicyclohexylethanediol (1,2-Ethanedidl,1,2-dicyclohexyl-)

摘要

The pinacol coupling reaction achieves reductive carbon-carbon bond formation from carbonyl compounds by low-valent early transition metals to give 1,2-diols. A catalytic system for the pinacol coupling was developed for the first time in our group. Catalytic, diastereoselective, and/or enantioselective methods have been reported recently. Organic reaction in water or aqueous media is of interest in organic synthesis from the vantage points of its cost, safety, and environmental concern. Therefore, the development of an efficient synthetic methodology to form a carbon-carbon bond in water or aqueous media appears to be of importance. Here, a vanadium-catalyzed pinacol coupling reaction in water is described.