Polymorphism in the jx-opioid receptor gene 0PRM1 A118G-An example of the enigma of genetic variability behind chronic pain syndromes

摘要

In this number of the Scandinavian Journal of Pain, Ulrika Hed-dini et al. [1] observed that single nucleotide polymorphism (SNP) variability in the 0PRM1 A118G(rs1799971) was related to chronic pain from vestibulodynia. The same A-allele in the OPRM1 A118G that increased risk for vestibulodynia was also related to higher experimental pain sensitivity. Women with vestibulodynia also had higher levels of plasma concentrations of the endogenous opioid beta-endorphin. Thus, in this study the evidence suggest that the G allele should protect against this sort of chronic pain.