Synthesis, Characterization, and Antimicrobial Activity of a Novel Proton Salt and Its Cu(II) Complex

摘要

A novel proton transfer compound (H2Ppz)(HDipic)2 (I) obtained from 2-(piperazin-1-yl)etha-nol (Ppz) and pyridine-2,6-dicarboxylic acid (H2Dipic) and its Cu(II) complex (H2Ppz)[Cu(Dipic)2] · 6H2O (II) have been prepared and characterized by elemental, spectral (~1H and ~(13)C NMR, IR and Uv-Vis) and thermal analyses. Magnetic measurement and single crystal X-ray diffraction methods have also been applied for compound II. The molecular structure of II consists of one 1-(2-hydroxyethyl)piperazine- 1,4-diium cation, one bis(pyridinium-2,6-dicarboxylate)Cu(II) anion and six uncoordinated water molecules. In complex II, the copper ion coordinates to two oxygen and one nitrogen atoms of two pyridine-2,6-dicarbox-ylate molecules forming an octahedral conformation. Furthermore, the synthesised compounds (I and II) were screened for their antimicrobial activities against Gram (—) (Escherichia coli and Pseudomonas aeruginosa) and Gram (+) (Staphylococcusaureus and Bacillus cereus). The results were reported, discussed and compared with the corresponding starting materials (H2Dipic and Ppz).