EXPLORING QSAR ANALYSIS OF CYCLOHEXANAMINE CLASS OF HUMAN SEROTONIN TRANSPORTERS (HSERT) INHIBITORY ACTIVITIES USING PHYSICOCHEMICAL PARAMETERS

摘要

QSAR studies have been made on a novel series of cyclohexanamine derivatives acting as potent and selective human serotonin transporters (HSERT). The HSERT inhibitory activities of these compounds were found to be dominantly controlled by steric and topological factors with inclusion of different indicator parameters such as I1 and I2 at different positions. Cross-validation methodology was performed for ascertaining predictive power of the QSAR models.