Synthesis, Antimicrobial and Antitubercular Activities of Some Novel Carboxamide Derivatives of 2-quinolones

摘要

A series of novel substituted N-(3-acetyl-2-oxoquinolin-1(2H)-yl)benzamide (AJQC1-AJQC12) have been synthesized upon refluxing 3-acetyl-1-amino-quinolin-2-one and substituted benzoic acid in the presence of dry redistilled pyridine and silicon tetrachloride as coupling agent. 3-acetyl-1-amino-quinolin-2-one (AJQ1-AJQ12) were synthesized from substituted 3-acetyl coumarin upon refluxing with hydrazine hydrate and ethanol.The structures of the final carboxamide derivatives were confirmed by IR, ~1H NMR and mass spectra. The synthesized compounds were screened for their antimicrobial activity by tube dilution method and antitubercular activity by microplate Alamar blue assay. Most of the compounds have exhibited promising antibacterial, antifungal and antitubercular activities.