Selective protonation at a C-F bond in the presence of an iridium-methyl bond gives diastereoselective carbon-fluorine bond activation and carbon-carbon bond formation. A new path to carbon stereocenters bearing fluorine atoms

摘要

Reaction of iridium-fluoroalkyl complexes with fluoride acceptors occurs with completely diastereoselective activation of a C-F bond and formation of a new C-C bond. Protonation occurs with complete selectivity at the C-F bond without any detectable formation of methane by protonation at the Ir-CH3 group. [References: 33]