首页> 外文期刊>Oriental Journal of Chemistry: An International Research Journal of Pure & Applied Chemistry >Development of new spectrophotometric methods for the determination of Alfuzosin hydrochloride in bulk and pharmaceutical formulations
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Development of new spectrophotometric methods for the determination of Alfuzosin hydrochloride in bulk and pharmaceutical formulations

机译:开发用于测定散装和药物制剂中盐酸阿夫唑嗪的新分光光度法

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摘要

Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and red- violet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling with Phloroglucinol and Resorcinol, exhibiting λ_(max) at 520 and 600 nm respectively. These methods obey Beer's law in the concentration ranges of 4-20 and 2-10 μg/mL These methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations.
机译:已经描述了两种简单而灵敏的方法A和B用于分光光度法测定盐酸阿夫唑嗪。这些方法基于形成紫色和红色-紫色色原的形成,当该药物用亚硝酸重氮化,然后与间苯三酚和间苯二酚偶合时,分别在520和600 nm处显示λ_(max)。这些方法在4-20和2-10μg/ mL的浓度范围内符合比尔定律。这些方法具有高度可重复性,已应用于多种药物制剂中。

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