Synthesis of Adducts of omicron-Quinone Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons with 2'-Deoxyribonucleosides

摘要

The first syntheses of the adducts formed in the reactions of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons(BPQ and BAQ)at 2'-deoxyadenosine and 2'-deoxyguanosine sites in DNA are reported.These syntheses entail Pd-catalyzed coupling of protected amine derivatives of catechols with suitably protected halopurine analogues of 2'-deoxyribonucleosides.