Efficient Syntheses of heterocycles and Crbocycles by Electrophilic Cyclization of Acetylenic Aldehydes and Ketones

摘要

Highly substituted oxygen heterocycles can be prepared in good yields at room temperature by reacting omicron(1-alkynyl)-substituted arene carbonyl compounds with NBS,I_2,ICI,p-O_2NC6H_4SCl,or PhSeBr and various alcohols or carbon-based nucleophiles.Naphthyl ketones and iodides are readily prepared by the reaction of 2-(1-alkynyl)arkynyl)arene-carboxaldehydes with I_2 and simple olefins or alkynes.