Catalytic Asymmetric Synthesis of Vicinal Diamine Derivatives through Enantioselective N-Allylation Using Chiral pi-Allyl Pd-Catalyst

摘要

N-Monoallylation of mesovicinal diamine bistrisylamides using a chiral pi-allyl-Pd catalyst proceeded in an enantioselective manner(up to 90% ee)to give desymmetrization products in good yields.The product was converted to the known sigma-receptor agonist in short steps.In addition,the present catalytic asymmetric N-allylation was applied to kinetic resolution of racem/c-diamide.