Delayed hypersensitivity reaction to Restylane (R) SubQ.

摘要

PURPOSE: To report on 4 patients who developed delayed hypersensitivity reactions to Restylane((R)) SubQ and their management. To our knowledge, no cases of delayed hypersensitivity to Restylane((R)) SubQ have been previously reported. METHODS: A retrospective case series of 4 patients who were treated with preperiosteal Restylane((R)) SubQ to their cheeks, for facial volume augmentation. All 4 patients were subsequently referred with delayed hypersensitivity reactions over a 4-month period. RESULTS: The hypersensitivity reactions occurred from 1 week to 4 months' post-cheek augmentation using Restylane((R)) SubQ. All patients had previously (and some since) been treated with other non-animal stabilized hyaluronic acid (NASHA) products without adverse effect. Hyaluronidase led to fast and effective resolution in all cases, although 2 of the patients required repeat treatment. CONCLUSION: Hyaluronidase was effective at treating the inflammatory reaction and breaking up the retained Restylane((R)) SubQ in all patients. Although Restylane((R)) SubQ should be avoided in these patients, in our experience this does not preclude them from using other similar NASHA products.