Biologically active oxazolones and their chemical immobilization on xanthat

摘要

The aim of the present paper is the characterization of two oxazolones resulting from the N-(m-, p-nitrobenzoyl)-L-asparagic acids, as to their biological action, as well as to their immobilization-by esteric bonds - on xanthan, in order to obtain a new polymer-drug system with controlled release of the active component. The influence of some parameters of the immobilization reaction (oxazolone/xanthan weight ratio, dicyclohexylcarboddiimide/oxazolone mole ratio) on the coupling efficiency was studied. The in vitro tests made evident the active component to be released from the macromolecular, support according to a "zero order" kinetics.