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Synergistic Antitumoral Effect of IL-12 Gene Cotransfected With Antiangiogenic Genes for Angiostatin, Endostatin, and Saxatilin

机译:IL-12基因与抗血管生成基因共转染血管生成抑制素,内皮抑素和萨克萨替林的协同抗肿瘤作用

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Previously, it was reported that the cotransfection of angiostatin Kl-3, endostatin, and saxatilin genes using cationic liposomes significantly inhibited tumor progression. IL-12 is a well-known immune modulator that promotes Thl-type antitumor immune responses and also induces antiangiogenic effects. In this study, we have examined the antitumoral function of the IL-12 gene cotransfected with antiangiogenic genes for angiostatin Kl-3, endostatin, and saxatilin by O,O'-dimyristyl-iV-lysyl glutamate (DMKE) cationic liposomes in a mouse tumor model. According to our results, the administration of the IL-12 gene or the genes for angiostatin Kl-3, endostatin, and saxatilin exhibited effective inhibition of B16BL6 melanoma growth in mice. In particular, intravenous administration of the IL-12 gene along with intratumoral administration of the three antiangiogenic genes synergistically inhibited the B16BL6 tumor growth. These results suggest that systemically expressed IL-12 enhances antitumoral efficacy of locally expressed antiangiogenic proteins.
机译:以前,有报道说使用阳离子脂质体共转染血管抑素K1-3,内皮抑素和萨克萨提林基因可以显着抑制肿瘤的进展。 IL-12是众所周知的免疫调节剂,可促进Thl型抗肿瘤免疫反应并诱导抗血管生成作用。在这项研究中,我们检查了O,O'-二肉豆蔻基-iV-谷氨酰赖氨酸谷氨酸盐(DMKE)阳离子脂质体与抗血管生成基因共转染的血管生成抑素K1-3,内皮抑素和沙克沙汀的IL-12基因的抗肿瘤功能肿瘤模型。根据我们的结果,IL-12基因或血管抑素K1-3,内皮抑素和萨克萨替林的基因的施用对小鼠的B16BL6黑色素瘤生长表现出有效的抑制作用。特别地,IL-12基因的静脉内给药与三个抗血管生成基因的肿瘤内给药协同地抑制了B16BL6肿瘤的生长。这些结果表明,系统表达的IL-12增强了局部表达的抗血管生成蛋白的抗肿瘤功效。

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