首页> 外文期刊>Oncology letters >Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients
【24h】

Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

机译:雌激素和孕激素受体在6例鼻腔血管平滑肌瘤中的表达

获取原文
获取原文并翻译 | 示例
       

摘要

Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients with nasal angioleiomyoma that were treated between 2004 and 2013. All patients underwent endoscopic surgery and were followed-up for 1-10 years. Resected tumors were investigated for the presence of ER and PR using immunoperoxidase staining. Of the 6 patients, 4 were men and 2 were woman. The mean age of the patients was 60.5 years. The tumors of the 6 patients were identified in the nasal septum, middle turbinate, inferior turbinate, lateral wall of the nasal cavity and nasal vestibule. The clinical manifestations reported by the patients consisted of a painless mass, recurrent epistaxis and nasal obstruction. There were no specific features observed in any of the patients using computed tomography or magnetic resonance imaging. All the patients underwent tumor dissection visualized with a nasal endoscope and recovered without recurrence or malignancy of the tumor post-surgery. Hematoxylin and eosin and immunoperoxidase staining confirmed the diagnosis of angioleiomyoma in all patients. In 5 patients the nuclei of the smooth muscle tumor cells markedly expressed ER and PR. To the best of our knowledge, the present study is the first to demonstrate that ER and PR are clearly expressed in nasal angioleiomyoma. The present study suggests that the sex hormones are possibly associated with the growth of angioleiomyoma.
机译:鼻腔血管平滑肌瘤极为罕见。文献中只有少量研究表明雌激素受体(ER)和孕激素受体(PR)在血管平滑肌瘤中表达,并且这些研究的结果不一致。本研究确定了6例2004年至2013年之间接受治疗的鼻血管平滑肌瘤患者。所有患者均接受了内窥镜手术,并进行了1-10年的随访。使用免疫过氧化物酶染色研究切除的肿瘤中ER和PR的存在。在6例患者中,男性4例,女性2例。患者的平均年龄为60.5岁。在鼻中隔,中鼻甲,下鼻甲,鼻腔侧壁和鼻前庭中发现了这6例患者的肿瘤。患者报告的临床表现包括无痛性肿块,复发性鼻axis和鼻塞。使用计算机断层扫描或磁共振成像在任何患者中均未观察到特定特征。所有患者均接受了鼻内窥镜显像的肿瘤解剖,并且在术后没有复发或恶性的情况下康复。苏木精和曙红及免疫过氧化物酶染色证实了所有患者的血管平滑肌瘤的诊断。在5名患者中,平滑肌肿瘤细胞核显着表达ER和PR。据我们所知,本研究是第一个证明ER和PR在鼻血管平滑肌瘤中明确表达的研究。本研究表明性激素可能与血管平滑肌瘤的生长有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号