After a quarter of a century struggling to decipher what is true and untrue about prostate cancer (PCa) and androgens, the review by Paul Mathew in this issue of ONCOLOGY comes as a breath of fresh air.[l] What a pleasure to read a new perspective on a problem that has been bedeviled by rigid ideas developed more than 70 years ago, like flies fixed in amber! When I completed my residency in urology in 1988, the prostate cancer and testosterone story was clear and without controversy. Prostate cancer was explained by what was called the androgen hypothesis:
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