COX2 regulation of breast cancer bone metastasis.

摘要

High expression levels of cyclooxygenase 2 expression and infiltration byregulatory T cells (Tregs) are often associated with tumor progression. We haverecently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to thetumor, suggesting that targeting specific PGE2 receptors may constitute avaluable approach to ablate the immuno-editing that occurs along with diseaseprogression.