Unraveling the physiological functions of exosome secretion by tumors.

摘要

To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters othersecretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumorprogression, but also that this phenomenon cannot be generalized to all tumorsand all exosomes.