Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediatedhematopoietic stem cell toxicity.

Schendel DJ; Frankenberger B.

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Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediatedhematopoietic stem cell toxicity.

机译：MHC限制杀虫剂和TCR介导的造血干细胞毒性对TCR基因治疗的局限性。

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The clinical use of lymphocytes engineered to express high affinity T-cellreceptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediatedkilling of hematopoietic stem cells. Specific clinical applications musttherefore be conceived to bypass these limitations.

机译：经过工程改造以表达对两种广泛表达的肿瘤相关抗原具有特异性的高亲和力T细胞受体（TCR）的淋巴细胞的临床应用受到MHC限制性淋巴细胞杀伤剂和TCR介导的造血干细胞杀伤力的强烈限制。因此，必须考虑特定的临床应用来绕开这些限制。

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《Oncoimmunology.》 |2013年第1期|共1页
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Schendel DJ; Frankenberger B.;
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正文语种 eng
中图分类肿瘤学;
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1. Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediatedhematopoietic stem cell toxicity. [J] . Schendel DJ, Frankenberger B. Oncoimmunology. . 2013,第1期

机译：MHC限制杀虫剂和TCR介导的造血干细胞毒性对TCR基因治疗的局限性。
2. TCR gene edited memory stem T cells for cancer immunotherapy [J] . Bonini C. Human gene therapy . 2016,第11期

机译：TCR基因编辑的记忆干T细胞用于癌症免疫治疗
3. Integrating Gene Correction in the Reprogramming and Transdifferentiation Processes: A One-Step Strategy to Overcome Stem Cell-Based Gene Therapy Limitations [J] . Seo-Young Lee, Sun-Ku Chung Stem cells international . 2016,第10期

机译：在重新编程和转染过程中积分基因校正：克服基于干细胞基因治疗限制的一步策略
4. Cell Processing For Gene and Cell therapy Protocols: Limitations and Opportunities' [C] . I. Slaper-cortenbach, E. Simonetti, C. Arts, International Symposium on Blood Transfusion . 2003

机译：基因和细胞治疗方案的细胞加工：限制和机遇
5. The Fault is in Our TCRS: Searching for on and Off-targets in T Cell Receptor Based Therapies [D] . Gejman, Ron S. 2018

机译：故障在我们的TCR中：在基于T细胞受体的疗法中寻找开启和偏离目标
6. Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity [O] . Dolores J. Schendel, Bernhard Frankenberger 2013

机译：MHC限制杀伤剂和TCR介导的造血干细胞毒性对TCR基因治疗的局限性
7. Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity [O] . Dolores J. Schendel, Bernhard Frankenberger 2013

机译：MHC受限制的丙酸酯和TCR介导的造血干细胞毒性的TCR基因治疗的限制
8. Retroviral Transfer of Human Mutated Thymidylate Synthase Gene into Hematopoietic Stem Cells for Protection from High-Dose Fluoropyrimidine Toxicity. [R] . Takebe, N., Gallo, R. 2001

机译：将人突变的胸苷酸合酶基因逆转录病毒转移到造血干细胞中以防止大剂量氟嘧啶毒性。

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediatedhematopoietic stem cell toxicity.

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