The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells:Implications for pancreatic cancer-driven immunosuppression.

摘要

An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advancedpancreatic ductal adenocarcinoma (PDAC) patients. Double negative(CD14(-)HLA-DR(-)) MDSCs are frequently induced by PDACs. In addition, byreleasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highlyimmunosuppressive CD33(+)CD14(+)HLA-DR(-) monocytic MDSCs expressing low levelsof cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface.