The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium.

摘要

Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidencesuggests that perturbed TLR4 signaling is linked to carcinogenesis. We haverecently demonstrated that the common human TLR4 variant D299G exertspro-inflammatory effects and drives malignant tumor progression in human coloncancer.