Association of Frailty with Patient-Report Outcomes and Major Clinical Determinants in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

摘要

Frailty is a clinical syndrome associated with a multisystemic decline in physiological reserve and increased vulnerability to potentially contributing to chronic disease onset and altering the prognosis and treatment of some diseases. Frailty is a risk factor for chronic obstructive pulmonary disease (COPD) exacerbation and is associated with worsening outcomes, such as acute exacerbations of COPD (AECOPD), hospitalization, length of stay, hospital readmissions, and mortality. Previous studies have reported that up to 19 of patients with stable COPD and 50 of patients with AECOPD experience frailty, which is related to their shared pathophysiological mechanisms, such as chronic inflammation, impaired neuroendocrine regulation, and immune system dysfunction. With the increase in global aging and the lifespan of individuals with chronic diseases, assessing and improving the condition of frail individuals, especially those with chronic diseases, has become a priority in public health.