The thermochemical characteristics of solution of DL-alpha-alanylglycine and DL-alpha-alanyl-DL-alpha-alanine in water-organic solvent mixtures at 298.15 K

摘要

The integral enthalpies of solution of DL-alpha-alanylglycine and DL-alpha-alanyl-DL-alpha-alanine in water - organic solvent ( acetonitrile, 1,4- dioxane, acetone, N, N- dimethylformamide, and N, N- dimethylsulfoxide) mixtures were measured at organic component concentrations x(2) = 0 - 0.4 mole fractions and T = 298.15 K. The standard enthalpies of solution (Delta(sol) H-o) and transfer (Delta H-tr(o)) of the peptides from water into mixed solvents were calculated. The influence of the structure and properties of solutes and mixture composition on the thermochemical characteristics of the peptides was considered. The enthalpy coefficients of pair interactions (h(xy)) of DL-alpha-alanylglycine and DL-alpha-alanyl-DL-alpha-alanine with organic solvent molecules were calculated. The h(xy) values were correlated with the properties of organic solvents using the Kamlet-Taft equation.