Preparation of Enantiomeric Pure(-)-(3R,4S)-1-Benzyl-3,4-epoxypiperidine and Enriched(-)-(R)-1-Benzyl-3-hydroxy-1,2,3,6-tetrahydropyridine by Kinetic Separation of(±)-1-Benzyl-3,4-epoxypiperidine under the Action of Chiral Lithium Amides

摘要

Enantiomeric pure(-)-(3R,4S)-1-benzyl-3,4-epoxypiperidine and(-)-(R)-1-benzyl-3-hydroxy-1,2,3,6-tetrahydropyridine with enantiomeric excess 61.9% were obtained by kinetic separation of(±)-1-benzyl-3,4-epoxypiperidine under the action of lithium salt(+)-(S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine.The sterical direction of the kinetic separation of(±)-1-benzyl-3,4-epoxypiperidine and absolute configurations of the target products were established.