Spiro Heterocyclization of 1H-Pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones with Furazan-3,4-diamine

摘要

We previously found[1]that 3-aroyl-1H-pyrrolo-[2,1-c][1,4]benzoxazine-1,2,4-triones react with o-phenylenediamine via successive attack by the amino groups of the binucleophile at the C~(3a)and C~4 carbon atoms of the substrate;the process is accompanied by cleavage of the oxazine ring at the C~4-O~5 and C~(3a)-N~(10)bonds and leads to the formation of 4-aryl-N-(2-hydroxyphenyl)-2,4-dioxo-3-[(Z)-3-oxo-3,4-dihydroquinoxalin-2(1H)-ylidene]butanamides.