The relationship between serum 25-hydroxyvitamin D, free estriol levels and complications during pregnancy, adverse pregnancy outcomes, and fetal growth in pregnant women from Chongqing

摘要

abstract_textpObjective: To explore the relationship between these factors and pregnancy complications, adverse pregnancy outcomes, and fetal growth, and to provide a reference for the reasonable supplementation of vitamin D in pregnant women in Chongqing, China. Methods: 267 pregnant women participated in our study from 2016 to 2018. The patients were divided into two groups according to their complications and adverse outcomes. They were divided into the healthy group (group A) and the group with pregnancy complications and adverse outcomes (group B). The clinical information and B-ultrasound data of the pregnant women were collected. 25(OH)D was done and the mu E3 levels were tested in the second trimester to calculate the mu E3 multiple of the medians of the MOM values. Results: The Serum 25(OH)D level was negatively correlated with adverse pregnancy outcomes (r=-0.121, P=0.048). There was a negative correlation between 25(OH)D level and 38w-39w6d fetal abdominal circumference (P=0.012), and there was a positive correlation with fetal birth length. The mu E3 level in the placental adhesion group was different from the level in the healthy group (P=0.044). mu E3 and mu E3 MOM were independent influencing factors of placental adhesion (P=0.003, OR=0.02), (P=0.004, OR=31.244). The mu E3 MOM value in the gestational diabetes group was different from the value in the healthy group (P=0.022). There was a significant difference in the mu E3 MOM value between the amniotic fluid index = 8 cm group and the 8 cm group (P=0.030). A statistical difference existed in the level of mu E3 between grade III and grade II in placental maturity (P=0.011). The mu E3 level was positively correlated with the biparietal diameter and with the femur length of the 15w-17w fetus (P=0.001), and negatively correlated with the biparietal diameter and femur length of the 33w-35w6d (P=0.022). The mu E3 MOM value was negatively correlated with the 33w-35w6d fetal biparietal diameter (P=0.020) and head circumference (P=0.042). Conclusion: The levels of 25(OH)D, mu E3, and mu E3 MOM are related to fetal growth. 25(OH)D, mu E3, and mu E3 MOM values have positive effects on preventing pregnancy complications and adverse outcomes./p/abstract_text