17 alpha- Hydroxyprogesterone Caproate for the Prevention of Adverse Neonatal Outcome in Multiple Pregnancies: A Randomized Controlled Trial

摘要

To the Editor: Lim et al are to be applauded for their well-performed trial aimed at identifying the efficacy of 17alpha-hydroxyprogesterone caproate to reduce neonatal morbidity in twin pregnancies. Tragically, however, instead of elements of the composite neonatal outcome showing benefit, and instead of the intervention being found to delay delivery, this trial finds the opposite. Exposure to this particular medication was related to neonates suffering severe respiratory distress significantly more, and exposed women experienced rupture of membranes significantly earlier than women who were administered placebo.