Chromosome instability is common in human cleavage-stage embryos: Editorial comment

摘要

Chromosome instability frequently occurs in human malignant solid tumors and is a hallmark of tumorigenesis, but has not been identified in other biological processes. A large number of studies have reported mosaic whole-chromosome imbalances, and there have been sporadic reports on rare segmental aneuploidies in human in vitro-fertilized embryos; these findings suggest that chromosome instability could also occur during human embryogenesis. There are few data on chromosomal imbalances in embryos from normal fertile women. No comprehensive studies have investigated genomic imbalances during embryogenesis.