Determination of the Sequence of Tautomericand Conformational Transformationsof Organic Compounds

摘要

Studies of organic compounds tautomerism are usually aimed to establish their tautomeric transformations using a variety of methods. However, for compounds containing multiple substituents capable of tautomerism, whereby capable of forming various tauto-mers, the fact of existence of a certain type of tautomerism is not enough. Only a few tautomers are usually realized from the many formally possible.Determination of the tautomeric content of the known compounds, which differ by the synthesis or purification methods, as well as by the nature of the environment in which they arc located, makes it possible to determine the sequence of actually occurring tautomeric transformations. Prior to our work a similar problem was not raised by the researchers. The isomers are known to have differing reactivity. The managing tautomeric equilibria allows to achieve improvement in the key technologies. The establishment of the tautomeric content and sequence of the tautomeric transformations are the necessary steps in this direction. The solution to this problem will show on an example of compounds, which is commonly attributed to the structure of 1,4,5,8-tetra-amino-9,10-anthraquinone I.