METHOD FOR IDENTIFYING ORGANIC NONPEPTIDE COMPOUND STABILIZING FUNCTIONAL CONFORMATION OF P53 FAMILY PROTEIN

摘要

PPROBLEM TO BE SOLVED: To provide a method for identifying organic nonpeptide compound stabilizing functional conformation of p53 family protein. PSOLUTION: The pharmaceutical compounds are provided in the field of cancer treatment, wherein the provided are ones capable of interacting with mutant and non-mutant forms of cancer-related regulatory proteins such that the mutant protein retains the capacity to properly interact with other macromolecules thereby restoring or stabilizing all or a portion of its wild type activity. Regulatory proteins include members of the p53 protein family such as p53, p63 and p73. The compounds are useful for cancer treatment. Methods for screening for such pharmacological compounds are also provided. PCOPYRIGHT: (C)2006,JPO&NCIPI