1-(TrifluoromethylsuIfonyl)-4,4-dimethyl-4-silapiperidine

摘要

After the synthesis of the first representatives of 4-silapiperidines (1,4-azasilinanes) in 1982 [1, 2], only a few works appeared in the literature [3-9] concerning these compounds showing biological activity [5-9], which were summarized in the recent review [10]. At the same time, 1,4-azasilinanes can be considered as N-protected primary amines, in which the organosilicon protecting group can be removed by treatment with alkali fluorides [3]. They also are interesting objects for structural investigations since for a series of N-trifluoromethylsulfonyl-substituted six-membered N-heterocycles an interesting stereo-dynamic behavior was found ([11, 12] and references -therein). N-Sulfonyl-substituted 4-silapiperidines R2Si(CH2CH2)2NSO2R' are not described in the literature. In the present work, we have synthesized their first representative, 1-trifluoro-methylsulfonyl-4,4-dimethyl-4-silapiperidine (II).