(1R,2S,5R)-Menthyl Phosphinate and Its Properties

摘要

Proceeding with our research into chiral esters of phosphorous acid we synthesized (lR,2S,5R)-menthyl phosphinate (I) [1-3].Compound I was prepared by the reaction of anhydrous hypophosphorous acid with (1R,2S,5R)-menthol in the presence of trimethyl orthoformate in THF.The reaction occurred smoothly and completely to give pure (lR,2S,5R)-menthyl phosphinate (I) in high yield.