Synthesis of Optically Active α-Aminophosphine Oxides and Enantioselective Membrane Transport of Acids with Their Participation

摘要

Previously, we have shown the prospect of using lipophilic α-aminophosphine oxides in the processes of membrane extraction for efficient and selective extraction of substrates of different nature, including mineral and organic acids [1]. We first attempted to carry out the enantioselective membrane transport of chiral carboxylic acids with optically active α-aminophosphine oxides. For their synthesis we used the Kabachnik-Fields reaction in the three-component system phosphinous acid-formaldehyde-amine.